Video on how stem cells work and develop
As stem cells work at stroke treatment
By numerous experiments on animals and clinical tests it is shown that transplantation of stem cells of a marrow promotes the fastest restoration after a stroke. But mechanisms of work of these cages are still insufficiently clear, and work of Japanese scientists from Hokkaido University School of Medicine in Sapporo is devoted to their studying.
In their research executed on mice by methods of an autoradiografiya and an immunohistochemistry was showed that introduction of stromalny cells of a marrow improves function of receptors specific to nervous cages gamma аминомаслянной acids (GABA). Cells of a marrow were genetically marked with green fluorescing protein and before introduction were cultivated in laboratory. Transplantation was carried out in стриатум in 7 days after the stroke caused to a perezhatiy cerebral artery. The transplanted cages migrated in periinfarktny area and regenerations of a nervous fabric promoted, restoring functions of a brain and eliminating neurologic symptoms of an illness. In 4 weeks after introduction the number of cages with GABA receptors in periinfarktny area was much higher, than at animals of control group whom cages didn't enter. Besides, a part of donor cages экспрессировала a characteristic marker of neurons - microtubule-associated protein 2.
By numerous experiments on animals and clinical tests it is shown that transplantation of stem cells of a marrow promotes the fastest restoration after a stroke. But mechanisms of work of these cages are still insufficiently clear, and work of Japanese scientists from Hokkaido University School of Medicine in Sapporo is devoted to their studying.
In their research executed on mice by methods of an autoradiografiya and an immunohistochemistry was showed that introduction of stromalny cells of a marrow improves function of receptors specific to nervous cages gamma аминомаслянной acids (GABA). Cells of a marrow were genetically marked with green fluorescing protein and before introduction were cultivated in laboratory. Transplantation was carried out in стриатум in 7 days after the stroke caused to a perezhatiy cerebral artery. The transplanted cages migrated in periinfarktny area and regenerations of a nervous fabric promoted, restoring functions of a brain and eliminating neurologic symptoms of an illness. In 4 weeks after introduction the number of cages with GABA receptors in periinfarktny area was much higher, than at animals of control group whom cages didn't enter. Besides, a part of donor cages экспрессировала a characteristic marker of neurons - microtubule-associated protein 2.
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