California Stem Cell Scientific Advisory Board Chairman Hans Keirstead To Speak At Acclaimed TEDxOrangeCoast Conference

California Stem Cell, Inc. (CSC) scientific advisory board chairman Hans S. Keirstead, Ph.D. will be among a notable group forward-thinking innovators, designers, educators, technologists, and socially concerned leaders who will speak at the 2012 TEDxOrangeCoast event in Costa Mesa on October 10.One of the world’s foremost stem cell researchers, Dr. Keirstead has pioneered several stem cell-based medical discoveries and policies, and founded the Sue and Bill Gross Stem Cell Research Center at UC Irvine. At TEDxOrangeCoast, he will highlight what it takes to overcome obstacles and succeed when translating stem cell discoveries into therapeutic reality. TEDxOrangeCoast will bring the spirit of the popular TED series to Orange County’s Segerstrom Center for the Arts, with more than 1500 guests expected to attend. Millions more will view video coverage of the event. “Stem cells have a greater potential than any other medical discovery to date,” said Keirstead. “They lie at the crossroads of academia, industry, government and religion. I am excited to have this opportunity to share my perspective on this incredible field.” Additional information regarding Dr. Keirstead and California Stem Cell’s pioneering work focused on creating stem cell-based therapies for patients suffering from cancer and life-threatening brain and spinal cord conditions, is available at http://californiastemcell.com/cgi-bin/pressrel About California Stem Cell California Stem Cell Inc. (CSC) is an Irvine, CA-based company with proprietary methods to generate human stem cell lines, expand them to clinically and commercially useful numbers, and differentiate them at extremely high purity using fully-defined, proprietary media and GMP processes. CSC is able to supply its human cell populations to companies and institutions worldwide for use in the development of therapies, efficacy screening or the creation of toxicity profiles for candidate drugs, and experimental research tools. CSC is currently focused on the development of stem cell-based therapies for spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s Disease), and metastatic cancers. Follow us on Twitter: http://twitter.com/castemcell About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized. (Subject to certain rules and regulations.) About TED TED is a nonprofit organization devoted to Ideas Worth Spreading. Started as a four-day conference in California 25 years ago, TED has grown to support those world-changing ideas with multiple initiatives. The annual TED Conference invites the world’s leading thinkers and doers to speak for 18 minutes. Their talks are then made available, free, at TED.com. TED speakers have included Bill Gates, Al Gore, Jane Goodall, Elizabeth Gilbert, Sir Richard Branson, Nandan Nilekani, Philippe Starck, Ngozi Okonjo-Iweala, Isabel Allende and former UK Prime Minister Gordon Brown. The annual TED Conference takes place each spring in Long Beach, California, along with the TEDActive simulcast in Palm Springs; the annual TEDGlobal conference is held each summer in Edinburgh, Scotland. TED’s media initiatives include TED.com, where new TEDTalks are posted daily, the recently launched TED-Ed platform for students and educators, the Open Translation Project, which provides subtitles and interactive transcripts as well as the ability for any TEDTalk to be translated by volunteers worldwide, and TEDBooks, short e-books by speakers that elaborate on a single idea originally presented on TED’s stage. TED has established the annual TED Prize, where exceptional individuals with a wish to change the world are given the opportunity to put their wishes into action; TEDx, which offers individuals or groups a way to host local, self-organized events around the world, and the TED Fellows program, helping world-changing innovators from around the globe to become part of the TED community and, with its help, amplify the impact of their remarkable projects and activities.

UCI стволовых клеток, лечение впервые в мире

Терапии острого повреждения спинного мозга разработанный ученым UC Irvine станет первым клинических испытаний в мире лечения с использованием эмбриональных стволовых клеток человека. Корпорация Geron из Менло-Парк объявил в пятницу, что за продуктами и лекарствами США одобрило планы по проведению первого этапа клинических испытаний пациенты в ряде мест в Соединенных Штатах. Терапия была создана UC Irvine ученый Ханс Keirstead и его коллега, Габриэль Нистор. "Это первый для спинного поля мозга, сначала для стволовых клеток поля", Keirstead заявил в пятницу. "Самое главное, что это победа для пациента сообщества, которые действительно негде повернуться. Есть никаких методов лечения травмы спинного мозга ». Лечения, успешно крыс, позволяющий человеческие эмбриональные стволовые клетки для создания новых тканей вокруг нейроны повреждены травмы спинного мозга, восстановление двигательной функции - возможно, в том числе позволяющие людям с парализованными ногами ходить. Она работает только с "острой" травмы - те, что произошло в течение 14 дней лечения - хотя Keirstead работает на аналогичной лечения хронического повреждения спинного мозга. В то время как драматические результаты, такие как возможность парализованных ходить Возможно, Keirstead сказал, что он также может быть доволен "дополнительных" Результат: восстановление кишечника, половой или сенсорной функции, например. Эмбриональные стволовые клетки человека. Фото предоставлено Кристи Hohenstein. "Думаю, что это будет означать только, чтобы получить использование большого пальца назад," сказал он. "Вы бы перейти от состояния полной и абсолютной зависимости к состоянию, когда вы можете управлять своим собственным инвалидным креслом, где можно ввести или работать с техникой, чтобы получить себя из постели по утрам." Geron в суде было отложено по FDA после первоначального одобрения в прошлом году, заявив, что необходимо пересмотреть больше данных безопасности. Keirstead сказал утверждении клинических испытаний выполняет обещание из Калифорнийского института регенеративной медицины, $ 3 млрд стволовых клеток инициативе одобрен избирателями Калифорнии в 2004 году. "Это неоспоримое доказательство того, что CIRM поставляет на обещании лечения с помощью стволовых клеток," Keirstead сказал. В заявлении Geron сказал целых семь медицинских центров по всей стране примут участие в клинических испытаниях, и что они будут названы, поскольку они "приходят в интернет и готовы записаться субъектов в исследовании." Эмбриональные стволовые клетки обладают потенциалом, чтобы стать много различных видов клеток в организме человека. Не только травмы спинного мозга, но болезнь Паркинсона, болезнь Альцгеймера и различные другие условия могут в один прекрасный день лечить с помощью стволовых клеток. Такое исследование может вызвать споры, когда стволовые клетки, полученные из человеческих эмбрионов, даже те, суждено быть отброшены - например, избыток эмбрионов, хранящихся в клиниках фертильности.

Stem-cell pioneer takes aim at M.S.

The decades-long dream of treating debilitating injury and illness with stem cells is quickly becoming reality. The world’s first test on patients of a treatment using human embryonic stem cells has cleared a year of safety trials with no adverse effects, according to Geron Corp. Meanwhile, a second clinical trial of another stem-cell treatment has begun in Switzerland. Both treatments target spinal cord injuries, and both were developed by scientists at UC Irvine. Stem cells have the potential to develop into a variety of cell types within the body. Some are derived from embryos, stirring controversy, but their promise is undeniable: allowing the paralyzed to walk, or reversing degenerative diseases such as Alzheimer’s or multiple sclerosis. Hans Keirstead, whose treatment for acute spinal cord injuries became the world’s first clinical trial using human embryonic stem cells, is pushing ahead to develop new treatments, and to increase the number of people who could be helped by those already being tested. Q. Are you doing further work on the stem-cell treatment for acute spinal-cord injury? A. I’m doing a lot of work in order to expand the patient population that might benefit from the treatment. I recently published a paper (about using) the treatment around the neck. Before we showed only that it worked down near the stomach, the thoracic region. We have to show that it works in rats before the FDA will allow us to go into humans. I published a paper showing it works just as well in the cervical (neck) region, as in the thoracic. I’m pretty happy about that.

Q. And you have new research efforts underway? A. I’m working on two new projects, and I’m really excited about them. Both are on chronic (long term) spinal-cord injuries. One involves getting rid of the scar that forms after an injury. If you get rid of the scar, that would make an old injury a young injury again. Therefore, you could apply all these new technologies that are emerging to treat acute (short term) spinal cord injury. It looks like we’ve been able to do it in a dish. We’ve grown spinal cord cells in a dish, we’ve made them become scarred, and we’re able to reverse that scar in a dish. Now we move on to rats. One thing that is very interesting: if it’s successful, this treatment also could be amenable to treatment of multiple sclerosis, which is a brain auto-immune disease, where one’s own immune system attacks the brain, and causes scarring. We would use the same approach to reverse the scarring, remove the scarring. This is one of the greatest challenges in central nervous system regeneration research. No one has been able to come close to doing it. It remains untouched. Q. Where does the scarring occurr in M.S.? A. Multiple places, various areas. Random areas. It would also be advantageous in the treatment of brain injuries and stroke, which also accumulate scars. The spinal cord tissue itself scars. Q. You’ve also worked on a treatment for spinal muscular atrophy, which typically kills children in their first years of life. A. It’s beyond the university now (an Irvine company called California Stem Cell is now working to prepare the treatment for its first clinical trial). The university is a place for innovation and invention; companies are a place for commercial development. Q. What is the second research initiative? A. The second one is a combination of what I think are two of the greatest developments in regeneration research. Oswald Steward at the UCI Reeve-Irvine Research Center recently took a technique, invented at Harvard, and moved it into spinal cord injury. He showed that he can get the spinal cord to grow better than it’s ever been able to grow before. How he did it is how everyone in the world is doing it using transgenic animals. They alter the genome of the entire animal in order to get it done. Clearly, you can’t do that in a human. What I’m doing is combining that technique into stem cells. You can, in effect, supercharge stem cell growth, then put them into an animal — soon, hopefully, with a human. We take this trick of supercharging the growth properties of the cell. Instead of applying it to the entire animal, we’re applying it only to the stem cells. I describe it to students as ‘stem cells on steroids.’ Genetic manipulation causes the stem cells to grow extraordinarily well. It would mean that transplanted cells would be able to grow quicker, and therefore also avoid scarring. Spinal cord injury is followed by a degenerative cascade, which involves disruption of blood and the death of many spinal cord cells, which releases toxins. Transplanted cells are prone to those same killers. By supercharging them, we may be able to allow them to integrate into the spinal cord, and survive that degenerative cascade. They may be able to knit the spinal cord together over greater distances. This would be a fundamental leap for the field, and could be applied to every transplant technique within the nervous system.

Dysfunction of stem structures of a brain

Palpitation, breath, temperature mode and appetite – is responsible for these vital functions a trunk of a brain which is on a site between a spinal cord and cerebral hemispheres. As a result of a craniocereberal trauma (including at childbirth) or after the ignored concussion the neurologist or the osteostalemate – can diagnose for the child or for the adult patient such violation as dysfunction of stem structures of a brain. The term dysfunction of a trunk of a brain testifies to problems in work of this department, and consequences can be the most unpleasant. To reveal deviations at early stages, follows in the first weeks after the birth of the kid or right after an injury of the head to seem to an osteostalemate. The last will be able quickly to reveal violations and to offer the individual scheme of treatment. Dysfunction of a trunk of a brain – reversible violation which can be eliminated literally for some sessions thanks to restoration of a full-fledged blood-groove and natural mobility of brain structures.

What diseases can be determined by nails

Nails can tell about a state of your health

Your nails can tell a lot of things about a state of your health. Faded, turned white, with abnormal pink or yellow hypostasis, spotty or wavy nails can be a symptom of a serious disease. Problems of a liver, lungs and heart can be shown in appearance of your nails, writes e-news.com.ua. Find out, what secrets can open your nails. The faded, decoloured nails. Very light or white nails are often tied with aging. But they also can be a symptom of serious diseases, such as: Anemia; Stagnant warm insufficiency; Liver diseases; General malnutrition or malyabsorbtion; White nails. If at the basis nails generally white color with dark strips, it can indicate problems with a liver, for example, hepatitis. Besides, it is often possible to notice the turned yellow nails and fingers - one more sign of problems with a liver. Yellow nails. One of the most common causes of yellowing of nails - a fungoid infection. As the infection progresses, the nail bed can exfoliate, and nails can be thickened and crumble. In rare instances yellow nails can testify to more serious conditions, such, as a serious illness of a thyroid gland, diseases of lungs, diabetes and psoriasis. Bluish nails. Bluish or violet (so-called tsianotichny) the shade of nails can mean that the organism doesn't receive oxygen enough. It can indicate an infectious disease of lungs, for example, on pneumonia. The nail which has turned blue at the basis, can appear a symptom of diabetes. Ridge nails. If the surface of a nail is dimply or wrinkled, it can appear an early symptom of psoriasis or inflammatory arthritis. At arthritis it is observed also decolouration of nails, a general malaise, and skin under nails gets a henna-red shade. Psoriasis (inflammatory disease of skin) in 10% of cases begins with defeat of nails. The fragile, burst, being stratified nails. Dry, fragile nails, it is frequent with deep longitudinal cracks, are connected with diseases of a thyroid gland. Disintegration or nail stratifying in combination with a yellowish shade are more probable at a fungoid infection. Edematous nail roller. If skin round a nail swelled up a little and reddened, it is defined as a nail inflammation. Puffiness can be result of a system red volchanka or other disease of connecting fabric. Dark strips under nails. Dark lines under nails have to be investigated as soon as possible. Sometimes they can be caused by a melanoma - the most dangerous form of a cancer of skin. Obgryzennye nails. Kusaniye of nails can be no more, than bad habit, but in certain cases is a sign of the prolonged disturbing condition demanding treatment. Obkusyvaniye and an obshchipyvaniye of nails happens is also connected with obsessivno-compulsive frustration. If you can't restrain, it should be discussed with the doctor.

Correspondent: The menu from the future. That people of Earth through some tens years will eat

Through some tens years already nobody will be confused by roast from grasshoppers: the mankind looks for an exit from global food crisis to which conduct population growth, shortage of natural resources and climate change, - Alexey Bondarev writes to No. 32 of the Correspondent magazine of August 17, 2012.

The phrase "British scientists" got in recent years a comical color in connection with a number of amusing researches which on pleasure

to a yellow press are conducted from time to time by scientists of Foggy Albion. For example, the press and numerous bloggers can't simply pass by such basic researches, as the device of an ideal sandwich, statistics on sexual orientation of breakers of rules of traffic and influence of color of a form of football players on quality of their game. Many inhabitants of the western countries grew, eating cheap meat, - the scientist speaks. - If meat becomes luxury, its shortage should be replaced with other products somehow Jokes on validity of local scientists are popular and in the Great Britain. Last year one of the largest newspapers accompanied news about the next outstanding opening by the following summary: "The British scientists found out that if the news text on the Internet begins with words the British scientists found out, 70% of people will believe in any nonsense which is written further in the text". Despite such reputation, many staff of the British universities still works over quite serious problems, and their some works are the best in the areas. In August of this year the group of the British scientists published results of research which in many respects shook representations about not so long-term future of mankind. About this scientific work considered as the debt to write all largest news agencies and mass media of caliber of BBC and The Times. Having analysed growth of population of a planet, a rise in prices for the food and climate changes, analysts came to an unfavourable conclusion that in two decades the mankind will already eat at all as today. Basic element of a modern diet, about what region or the country there would be a speech, is a meat. With it also will arise most of all problems, Morgan Gay, one of authors of research claims. Meat price continuously grows in the last ten years and while nothing foretells delay of this growth Meat price continuously grows in the last ten years and while nothing foretells delay of this growth. In July, 2011 of meat price reached an absolute record. It is more than that, according to forecasts of experts, in the closest five-seven years of meat price in the majority of the countries of the world will grow still twice. And actually it becomes luxury goods, concludes Gay. "Many inhabitants of the western countries grew, eating cheap meat, - the scientist speaks. - If meat becomes luxury, its shortage should be replaced somehow with other products". But with what and how? Here the main question which was raised before themselves by British, having offered some options of succession of events. Any of them conducts to huge changes in a habitual diet and even a way of life, the American biologist David Mancini speaks. Stake from grasshoppers According to Geya, the mini-cattle will be the most probable candidate for a role of a relief of meat in a diet of the modern person - exactly so scientists call insects.

Leukocytosis: FOUNDATIONS OF CLINICAL SURVEY

Breviary N. Abramson, B. Melton Am Fam Physician 2000; 62:2053-60 Leukocytosis - the presence in the blood of more than 11 × / 109 / L, white blood cells - often discover during a routine laboratory examination. Increasing the number of white blood cells usually displays a normal response of the bone marrow to the infectious or inflammatory process. Sometimes leukocytosis is a manifestation of the primary disease of the bone marrow associated with the synthesis, maturation and death (apoptosis) of white blood cells, which leads to leukemia and myeloproliferative diseases. Often, family doctors can establish the etiology of leukocytosis by history and physical examination, together with the results of the expanded blood count.

Synthesis, maturation and survival of leukocytes Of the common progenitor cells - stem cells located in the bone marrow, are like erythroblasts and myeloblasts megakarioblasty. 3/4 of all bone marrow cells that contain nuclei related to the synthesis of leukocytes. As a result of the proliferation and differentiation of these stem cells produce granulocytes (neutrophils, eosinophils and basophils), monocytes and lymphocytes. Every day is synthesized approximately 1.6 billion granulocytes per kg body weight, 50-75% of which are neutrophils. More often increase in neutrophils (neutrophilia) than eosinophils and basophils. On the maturation of white blood cells in the bone marrow and their release into the circulating bed koloniostimuliruyuschie influence factors, interleukins, tumor necrosis factor, and complement components. Approximately 90% of the white blood cells are in custody in the bone marrow, 2-3% - circulate in the blood, and 7-8% are located in the tissues of the body. The cells contained in the bone marrow, are divided into two populations: those that are in the phase of DNA synthesis and maturation, and cell depot, awaiting its release into the circulation. With depot mature cells the body can respond quickly to the need for leukocytes, increasing their number doubled or tripled in just 4-5 hours. In the reaction of the bone marrow to infection or inflammation of the majority of the cells are polymorphonuclear leukocytes. Pool of circulating neutrophils is divided into two classes: those cells circulate freely, and others - are placed along the walls of blood vessels. With stimulation caused infection, inflammation, influence of drugs or metabolic toxins latter cells leave the depot and replenish freely circulating pool. As soon as the white blood cell enters the tsirkulyartornoe course and tissue survival of the cell is only a few hours. The life span of leukocytes is 11-16 days, most of which goes to mature and remain in custody in the bone marrow. The etiology of leukocytosis A survey on the leucocytosis begins with differentiation of two main reasons: 1) the proper response of normal bone marrow to external stimuli, and 2) the primary manifestations of the disease of the bone marrow. Physiological mechanisms of leukocytosis are presented in Table 1. Table 1. Pathophysiological mechanisms of leukocytosis The normal reaction of the bone marrow • Infection • Inflammation: necrosis, stroke, burns, arthritis • Stress: excessive stress, cramps, anxiety, anesthesia • The remedy: corticosteroids, lithium, β-agonists • Trauma: splenektomiya • Hemolytic anemia • leukemoid reaction Pathological reaction of the bone marrow • Acute leukemia • Chronic leukemia • Myeloproliferative disease Leukocytosis with normal bone marrow function In most cases, leukocytosis results from normal bone marrow response to infection or inflammation, the majority of cells - polymorphonuclear leukocytes (PMN). Circulating PMN and less mature forms (for example, a stick-nucleated cells and meta-myelocytes) migrate to the site of injury or infection. This process is accompanied by the release of leukocytes from the depot ("left shift"). Leukocytosis inflammatory genesis occurs when tissue necrosis, heart attack, burns and arthritis. Leukocytosis may also occur due to physical or emotional stress. This is a transient process that is not associated with the synthesis in bone marrow or release into the circulation of immature cells. Stress is leukocytosis with excessive stress, cramps, anxiety, anesthesia, and the appointment of adrenaline and disappears for several hours after the removal of a provoking factor. The remedy, splenektomiya, hemolytic anemia, and malignant diseases can also cause leukocytosis. Medications that commonly cause leukocytosis: corticosteroids, lithium and β-agonists. Splenektomiya causes transient leukocytosis, which lasts a few weeks or months. Hemolytic anemia with increased synthesis of red blood cells are non-specific increase in the synthesis and release of circulating white blood cells, it is believed that this is due to the action of growth factors. Cancers are also factors leukocytosis (and sometimes thrombocytosis) tumor nonspecifically stimulates the bone marrow to synthesize white blood cells. Overreaction to the side of leukocytes (ie, leukocytosis over 50 × / 109 / l) due to the action of factors beyond the borders of the bone marrow, called "leukemoid reaction." Usually it is caused by relatively benign processes (eg, infection or inflammation), although the most serious, though, and the rarest factor may be the malignant process. As mentioned, the increase in the number of neutrophils is the most common cause of leukocytosis, but also may increase the number and other subpopulations of leukocytes (eosinophils, basophils, lymphocytes and monocytes).